Background The optimal timing and expected postoperative course of coronary artery bypass grafting (CABG) after asymptomatic coronavirus disease 2019 (COVID-19) remain uncertain. Evidence guiding cardiac surgical practice has largely been extrapolated from mixed surgical cohorts or broader cardiac surgery series rather than from isolated CABG populations.Methods This retrospective single-center cohort study included adults who underwent isolated CABG between 2021 and 2022. Patients with a documented history of asymptomatic preoperative SARS-CoV-2 infection were compared with patients without documented prior COVID-19. Preoperative, intraoperative, and postoperative variables were extracted from institutional records. The primary analysis compared early clinical outcomes, respiratory parameters, transfusion requirements, inflammatory biomarkers, and mortality between groups. A prespecified subgroup analysis compared patients undergoing surgery within 4 weeks versus at least 4 weeks after asymptomatic infection.Results Seventy-six patients met eligibility criteria: 37 with prior asymptomatic COVID-19 and 39 without prior COVID-19. Mean age was 63.4 ± 8.5 years, and 81.6% were male. Baseline demographics, comorbidities, left ventricular ejection fraction, EuroSCORE II, operative priority, number of grafted vessels, cardiopulmonary bypass time, cross-clamp time, extubation time, intensive care unit stay, hospital stay, oxygen requirement, and transfusion exposure were similar between groups. Postoperative complication rates were higher in the prior-COVID group (16.2% vs 0%; P = 0.011), whereas mortality remained low and not significantly different (2.7% vs 0%; P = 0.487). Longitudinal laboratory analyses showed expected perioperative inflammatory and hematologic changes within both groups, without consistent between-group separation. Among patients with prior asymptomatic infection, surgery performed within 4 weeks of infection was not associated with significantly worse early outcomes than surgery performed later.Conclusions In this cohort, prior asymptomatic SARS-CoV-2 infection was not associated with a broad deterioration in early postoperative outcomes after isolated CABG, although postoperative complications occurred more frequently in the prior-COVID group. These findings support a severity-informed rather than a uniform delay-based approach to CABG scheduling after asymptomatic infection, while underscoring the need for larger multicenter studies incorporating vaccination status and longer follow-up.Trial Registration This study was not registered as it does not meet the criteria for a clinical trial registration.