Regional properties are common for neurons in the mammalian visual system. In the retina, some neurons change their morphology and light responses with their retinal locations. However, it is unclear whether the region-specific light responses within the same cell type maintains under various light conditions and how these region-specific light responses are generated. Here, we focused on sustained On alpha retinal ganglion cells (sOn αRGCs) which have stronger surround inhibition in the temporal than the nasal retina. By recording light evoked electrical signals in single sOn αRGCs from the temporal and nasal retina, we find that regional difference in surround inhibition present under high photopic conditions but not observable under low photopic conditions. Our pharmacological data show that this regional difference under high photopic conditions relies on GABAergic inputs. Furthermore, we find that the different surround inhibition along the temporal-nasal axis is not present in another RGC type – tOff αRGCs, suggesting that not all RGCs have regional difference in surround inhibition, such as tOff αRGCs. Thus, our data support the notion that the regional surround inhibition in RGCs depend on light stimuli and is type-specific, which might be related to type-specific signal processing under various light conditions.