Background Male involvement in antenatal care (ANC) is vital to improving maternal health outcomes, yet remains limited in many parts of sub-Saharan Africa. This study explores how sociodemographic factors influence male awareness, attitudes, and participation in ANC within Denkyembour District, Ghana.Method Using a cross-sectional design and structured questionnaires administered via the KOBO Collect app, data were gathered from 350 male respondents who were either partners of pregnant women or fathers of children under one year.Results Findings reveal high levels of awareness (92.9%) and participation (75.4%) in ANC, with most men perceiving their involvement as motivational for their partners. However, barriers such as occupational demands (40%), distance to health facilities (37.7%), and financial constraints (10%) hinder consistent engagement. Sociodemographic variables, including age, education, occupation, marital status, and religion, were significantly associated (p < 0.00001) with willingness to attend ANC in the future.Conclusion The study highlights the importance of culturally sensitive and structurally appropriate interventions that encourage male involvement in maternal health, thereby helping to reduce maternal mortality in Ghana and similar settings.