Background Cardiovascular disorders are the leading global cause of death, with more premature mortality in middle-income countries (MICs) than in high-income countries (HICs), challenging health systems. However, data on cardiovascular-related hospital admissions in MICs remain limited. This study assessed such admissions in Suriname, a MIC in South America with high cardiovascular mortality.Methods We conducted a retrospective, hospital-based repeated cross-sectional study using discharge records from Suriname’s three largest public hospitals (71.8% of national admissions). Diagnoses were classified using ICD-10 codes for Cancer, Diabetes (DM), Ischemic Heart Disease (IHD), Stroke, Heart Failure (HF), Renal Disease (RD), and Other Cardiac Diseases (OCD). Age-standardized rates (ASR) were calculated using the WHO standard population. Trends were analyzed using log-linear regression to estimate Annual Percentage Change (APC) with 95% confidence intervals.Results Total age-standardized admissions increased by 6.6% annually (APC 6.6, 95% CI 4.2–9.1). The largest rise occurred in renal disease admissions (APC 14.6) and mortality (APC 11.4). IHD and HF admissions increased steadily, while OCD mortality rose most sharply (APC 19.2). Overall mortality increased (APC 8.2), more in males (10.2%) than females (6.3%), widening the sex gap by 29%. Cancer and diabetes admissions remained stable.Conclusion Suriname faces a rapidly increasing hospital burden and mortality driven by cardiovascular and renal diseases. The sharp rise in renal disease and widening male mortality gap highlight the need for sex-specific prevention and improved hypertension and diabetes management, alongside expanded nephrology and cardiac care capacity.