Background Robot-assisted radical cystectomy (RARC) has already been a standard treatment for muscle-invasive bladder cancer, with multiport laparoscopic approaches being well-established. However, single-port laparoscopic ERC has emerged as a less invasive alternative, though its comparative efficacy and safety remain understudied.Methods We conducted a retrospective study comparing 72 patients who underwent multiport ERC with 31 patients who received single-port ERC. Perioperative outcomes, including operative time, estimated blood loss (EBL), length of stay (LOS), lymph node yield, and 90-day complications were analyzed.Results There were no significant differences in operative time (211.0 vs. 206.0 min, p = 0.720), EBL (175.5 vs. 147.0 mL, p = 0.292), LOS (12.5 vs. 11.0 days, p = 0.422), or lymph node yield (17.5 vs. 15.0 nodes, p = 0.164) between the two groups. While readmission rates (29.2% vs 19.4%, p = 0.299) and positive surgical margins (9.7% vs. 6.5%, p = 0.720) were similar, single-port ERC was associated with a significantly lower rate of 90-day complications (31.9% vs 12.9%, p = 0.044). No differences were observed in major complications such as ileus ,bleeding and UTI.Conclusions Single-port ERC is a safe and feasible alternative to multiport ERC, offering comparable perioperative outcomes with a reduced risk of early complications. These findings support the potential of single-port techniques to enhance patient recovery while maintaining oncologic efficacy in bladder cancer surgery.