Purpose: Early diagnosis of tumor recurrence or metastasis is critical for prolonging survival in patients with tumor. Such diagnosis requires not only high accuracy and flexibility but also clinical feasibility. Peripheral blood tests carry abundant information that may indicate tumor progression.  Methods: Through retrospectively collecting clinical data of non-metastatic renal cell carcinoma patients, analyzing data with the methods of Cox regression and receiver operator characteristic curve, we constructed a preoperative formula along with postoperative neutrophil-lymphocyte ratio progression as an inflammation-related indicator to predict the progression of renal cell carcinoma.  Results: The inflammation-related indicator showed good predictive ability for recurrence or metastasis in surgically treated patients with renal cell carcinoma, with superior prognostic performance compared with other existing clinical prognosis indicators.  Conclusion: By integrating preoperative and postoperative parameters, this inflammation‑related biomarker enables dynamic monitoring of tumor progression and provides a cost‑effective and efficient tool for routine clinical practice.This retrospective study was approved by the Ethics Committee of the 2nd affiliated hospital of Xi’an Jiaotong University (ID:2021033).