Case Report 2026-04-21 posted v1

Silent Pulmonary Arteriovenous Malformation in Hereditary Hemorrhagic Telangiectasia Presenting as a Brain Abscess: A Case Report

A
Aisha Ghazanfar Liaquat National Hospital
S
Saba Zaidi Liaquat National Hospital
S
Shafiq Ur Rehman Liaquat National Hospital
H
Hazim Brohi Liaquat National Hospital

Abstract

Introduction: Pulmonary arteriovenous malformations (PAVMs) are abnormal vascular connections that predispose to paradoxical embolism and brain abscess formation. They often remain undetected until severe complications occur, posing significant diagnostic challenges. Case Presentation: We report the case of a young woman who presented with new-onset focal seizures.  A contrast-enhanced MRI of the brain showed an encapsulated abscess, which was managed with early surgical evacuation and antibiotic therapy. During her recovery, she developed an unexpected respiratory decline, which led to further investigation. CT pulmonary angiography identified a pulmonary arteriovenous malformation, and she subsequently underwent successful angioembolization. In the context of her clinical features, these findings raised concern for an underlying diagnosis of hereditary hemorrhagic telangiectasia (HHT). Conclusion:­ This case highlights the importance of evaluating pulmonary AVMs as a potential source of brain abscesses, particularly in young patients without apparent risk factors. Early recognition and management of PAVMs, including angioembolization, are essential to prevent recurrence and improve outcomes.

Citation Information

@article{aishaghazanfar2026,
  title={Silent Pulmonary Arteriovenous Malformation in Hereditary Hemorrhagic Telangiectasia Presenting as a Brain Abscess: A Case Report},
  author={Aisha Ghazanfar and Saba Zaidi and Shafiq Ur Rehman and Hazim Brohi},
  journal={Research Square},
  year={2026},
  doi={https://doi.org/10.21203/rs.3.rs-9335231/v1}
}
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