Background Open globe injuries with intraocular foreign bodies(IOFBs)are characterized by complexity and diversity.The removal of IOFBs poses a unique challenge to ophthalmic surgeons.Particularly for large or irregular non-magnetic IOFBs in the posterior pole, considerable difficulty exists.We report a novel technique of a simple slipknot construction by using 8 − 0 polyglactin suture (Vicryl, Ethicon) to remove IOFBs effectively and safely.Case presentation A 50-year-old healthy female sustained a left eye glass explosion injury while working without wearing goggles 8 days ago. Despite debridement and suturing, the patient still experienced blurred vision and was subsequently referred to the our ophthalmology department .An IOFB in vitreum was indicated by B-ultrasound and orbital CT,which was approximately 15mm in length and 4 mm in width, with a glass-like nature.We performed pars plana vitrectomy (PPV) combined with IOFB removal by utilizing a simple slipknot made with 8 − 0 Vicryl suture in the left eye for the patient, with no complications observed.Conclusion This kind of slipknot enables safe and rapid removal of IOFBs, featuring economical and simple to construct from readily available consumables,which make it particularly suitable for large and irregular IOFBs.The tight ligation effectively prevents accidental detachment of the IOFBs, thereby avoiding iatrogenic retinal injury.