SinoXivThe impact of Sjögren's disease on health related quality of life and its relationship with socioeconomic variables in Argentina
Abstract
Objectives To describe Health-related quality of life (HRQol) in adult patients with Sjögren disease (SD) and analyze its association with clinical manifestations, and socioeconomic condition.Methods Patients with diagnosis of SD fulfilling classification criteria 2002/2016 were included in a multicentric, cross-sectional study. For assessment of HRQoL, SF-36 questionnaire was used; eight multiple linear regression models were performed.Results 252 patients were included, 98,38% were female, mean age of 52,64 years (± 14,84). The mean SF-36 domains values were: general health 48,84 (± 22,24), physical role functioning 43,06 (± 42,71), body pain 52,87 (± 25,92), physical functioning 64,34 (± 26,81), vitality 45,93 (± 20,83), social functioning 62,10 (± 27,36), emotional role functioning 51,72 (± 43,24) and mental health 57,10 (± 21,19). The most frequent variables associated independently with all SF-36 domains were: fatigue, xerostomy, depression and anxiety. Statistically significant differences between public and private centers were observed in the following domains: physical role functioning [34,93 (± 41,86) vs 54,41(± 41,39)], body pain [48,96 (± 26,91) vs 58,73 (± 23,15)] and emotional role functioning [46,81 (± 44,14) vs 59,48 (± 41,33)]. Statistically significant differences among patients with lower and those with full or higher secondary education level, in physical role functioning [36,65 (± 41,25) vs 47,29 (± 43,18)] and body pain [47,71 (± 42,39) vs 56,45 (± 52,33)] were found.Conclusion We found a negative impact of SD in HRQoL, being xerostomy and fatigue the most frequent manifestations associated to the different domains of the SF-36.
Citation Information
@article{anastasiasecco2026,
title={The impact of Sjögren's disease on health related quality of life and its relationship with socioeconomic variables in Argentina},
author={Anastasia Secco and Marisel Vanesa Bejarano and Gloria Crespo Amaya and Cecilia Asnal and Paula Pucci and Crisitina Amitrano and Silvia Papasidero and Julia Demarchi and Laura Encinas and Francisco Caeiro and Carla Gobbi and Eduardo Albiero and Andrea Gomez and Rodrigo Aguila Maldonado and Mercedes Garcia and Maria Ángeles Gallardo and Enrique Roberto Soriano Guppy and Laura Raiti and Gabriela Salvatierra and Alicia Eimon and Antonio Carlos Catalán Pellet},
journal={Advances in Rheumatology},
year={2026},
doi={https://doi.org/10.21203/rs.3.rs-9004253/v1}
}
