SinoXivType 2 Diabetes (T2D) is a heterogeneous metabolic disorder driven by the interplay between endocrine stress and glucose regulation. We adapt an 18-variable ordinary differential equation (ODE) model ...
Organ-specific aging measures have recently gained growing attention. Still, the interpretation of the contributing factors, biological mechanism and relevance of the physiological insights remain unc...
Met1-linked ubiquitin (Met1-Ub) assembled by LUBAC crucially regulates immune receptor signalling. However, the regulation of LUBAC’s function remains widely debated. Here, we reveal that the interact...
Assessments of future human survivability under extreme heat with climate change have recently been anchored to a theoretical physiological tipping point: 6 hours of exposure to a wet-bulb temperature...
Dementia mortality and projected inequalities in the United States, 1999–2050: a CDC WONDER analysis
Background:Dementia is a leading cause of death in older adults in the United States, and the population at greatest risk is expanding as post-war birth cohorts move through later life. Existing natio...
A pipeline for improved 16S rRNA gene-based phylogeny and diversity analyses of Bacteria and Archaea
The LTP database compiling 16S rRNA gene sequences of all type strains of Bacteria and Archaea has served taxonomists for two decades. Here we report the LTPlus, a manually curated and aligned databas...
Background: In India’s rapidly expanding industrial sector, complex occupational hand trauma represents a silent epidemic among manual laborers. Compounded by climate-driven heat stress, these injurie...
Background Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed in oncology settings, yet their direct effects on endometrial cancer cell fate and survival signaling remain unclear....
Background: Eating disorders remain complex and costly conditions, and while evidence‑based treatments address behavioural and weight‑related symptoms, they often neglect embodied aspects of recovery....
Background Patients with obesity are frequently excluded from Helicobacter pylori (H pylori) therapy trials, despite physiological alterations that may impair antibiotic pharmacokinetics. Suboptimal e...
