SinoXivThe autophagy-lysosome pathway, governed by transcription factor EB (TFEB), is critical in cellular degradation and signal transduction. Dysregulation of this pathway or TFEB contributes to aging, tum...
Background Researchers identified “preparing patients to be active in innovations” as one of the top five most effective implementation strategies; this included educating patients to be engaged in th...
Purpose To develop and verify a physiologically based pharmacokinetic (PBPK) modeling strategy for mithramycin (MTM) and its analog, MTMSA-Trp, with the aim of projecting first-in-human plasma pharmac...
Background Cognitive learning approaches are important in nursing education because they support analytical thinking, decision-making, and self-regulated learning processes. Competencies such as probl...
The extreme confinement and directional propagation of polaritons in highly anisotropic van der Waals materials have recently opened new opportunities for nanoscale light control. In particular, these...
Background Relapse after orthodontic tooth movement (OTM) is frequently observed, and adjunctive therapy during the retention phase is often required to prevent it. Photobiomodulation therapy (PBMT) m...
Background: Despite the scale-up of antiretroviral therapy (ART), active tuberculosis (TB) remains a major complication among people living with HIV (PLHIV). This study identified epidemiological risk...
With Black women facing disproportionately worse health outcomes during and after pregnancy, innovations in digital mental health provide an avenue to support the mental wellbeing of this population. ...
This in-depth investigation employs network pharmacology and molecular docking methodologies to analyse various phytocompounds extracted from the hamamelis plant, with a specific focus on uncovering p...
Background Systematic and quantitative evaluation of China's hospice and palliative care (HPC) policy corpus remains limited. This study addresses this gap through an integrated three-dimensional anal...
