SinoXivBackground: The objective of Phase I/II dose-finding design is to determine the Optimal Biological Dose(OBD) that is acceptably safe and demonstrates sufficient anti-tumor activity by maximizing a pre...
Background Suicide is a leading cause of death among adolescents and emerging adults. Suicidality is a multidimensional construct that includes suicidal ideation (SI), self-harm (SH), suicide attempts...
Background: Pulmonary infections remain a major cause of global morbidity and mortality, particularly in low- and middle-income countries. The rapid emergence of antimicrobial resistance, including mu...
Background Improper disposal of domestic unused and expired medicines is a source for environmental contamination. This pharmaceutical pollution pathway is also an under-recognized cause of antimicrob...
Background: Community-acquired pneumonia is an established independent risk factor for atherosclerosis, yet the molecular mechanisms translating acute pulmonary infection into chronic vascular patholo...
Background: First-episode psychosis (FEP) is a critical stage in psychotic disorders, in terms of clinical and functional outcome. Deficits in facial emotion recognition and impaired clinical insight ...
The atmospheric boundary layer (ABL) is a turbulent “vertical conversation” that couples motions across height and time in strongly stability-dependent ways, yet most learning systems neither reveal n...
Background Neoadjuvant therapy (NAT) is crucial for locally advanced breast cancer, but post-NAT lymph node assessment is challenging due to histological changes. Current methods like immunohistochemi...
Background Hypertension is a leading modifiable cause of cardiovascular mortality globally. Nationally representative data on the full hypertension care cascade prevalence, awareness, treatment, and b...
Objective: This study aimed to develop and evaluate a multi-stage optimisation strategy based on the thirst management model to alleviate perioperative thirst and dry mouth symptoms in patients with g...
