SinoXivThe increasing demand for personalized skincare solutions highlights a significant gap: many consumers struggle to findsuitable products without professional guidance. While the commercial potential f...
Met1-linked ubiquitin (Met1-Ub) assembled by LUBAC crucially regulates immune receptor signalling. However, the regulation of LUBAC’s function remains widely debated. Here, we reveal that the interact...
The strength prediction of adhesive-bonded single lap joints (SLJs) is essential for reliable joint design. However, due to the non-linear interactions between geometrical parameters and material prop...
Dementia mortality and projected inequalities in the United States, 1999–2050: a CDC WONDER analysis
Background:Dementia is a leading cause of death in older adults in the United States, and the population at greatest risk is expanding as post-war birth cohorts move through later life. Existing natio...
A pipeline for improved 16S rRNA gene-based phylogeny and diversity analyses of Bacteria and Archaea
The LTP database compiling 16S rRNA gene sequences of all type strains of Bacteria and Archaea has served taxonomists for two decades. Here we report the LTPlus, a manually curated and aligned databas...
Background Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed in oncology settings, yet their direct effects on endometrial cancer cell fate and survival signaling remain unclear....
Background Patients with obesity are frequently excluded from Helicobacter pylori (H pylori) therapy trials, despite physiological alterations that may impair antibiotic pharmacokinetics. Suboptimal e...
Contemporary agile development processes optimize for velocity and functional completeness, yet systematically disregard ethical considerations. This dilemma exposes a significant ethics gap, as organ...
The rapid increase in atmospheric CO₂ concentrations remains a major driver of global climate change, making the development of high-performance carbon capture materials essential. These materials mus...
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 15% of childhood ALL and is associated with a high risk of relapse, with ~ 25% of patients failing conventional therapy...
