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Open Access Academic Papers from Research Square

3 results found
Research Article posted

Ginkgolide B improves mitochondrial biogenesis and cognitive deficits through histone H4 lysine 5 acetylation in APP/PS1 mice

Yi-pei Li, Juan Gong, Liu Yang, Rui-rui Peng, Li Jin, Fang Wang, Xiaoyuan Zhao, Li Wang

Ginkgolide B (GB), a diterpenoid lactone compound derived from Ginkgo biloba extract, exhibits anti-inflammatory and inhibits neuroexcitotoxicity. However, its specific pharmacological effects and mec...

Research Square 2026-04-21 rs-9230899
Alzheimer’s disease Ginkgolide B mitochondrial biogenesis histone acetylation amyloidβ
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Research Article posted

A Multi-Scale View of Alzheimer’s Disease: Linking Cellular Dysfunction to Brain Activity

Sahaana Vasudevan

Alzheimer’s disease is a progressive neurodegenerative disorder characterized by cognitive decline and widespread cellular dysfunction. While individual pathological features such as mitochondrial imp...

Research Square 2026-04-21 rs-9458287
Alzheimer’s disease neurodegeneration multi-scale analysis mitochondrial dysfunction lysosomal dysfunction oxidative stress EEG electroencephalography systems biology metabolic stress cognitive decline secondary data analysis
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Short Report under-review

Chronic lithium exposure reshapes PI3K–mTOR-linked proteostatic networks in the hippocampus of an Alzheimer’s disease mouse model

Caíque de Oliveira Portugal Couto, Maria Luiza Hass das Eiras, João Lucas Juliao de Morais, Carlos Wagner Leal Cordeiro Júnior, Orestes Vicente Forlenza, VANESSA De Jesus Rodrigues de Paula

Alzheimer’s disease (AD) involves a progressive loss of neuronal integrity in which chronic neuroinflammation is increasingly recognized as a contributing factor. Sustained activation of innate immune...

Molecular Neurobiology 2026-04-20 rs-9077098
Phosphatidylinositol-3-kinase Alzheimer's disease Lithium Ontological pathways Neuroplasticity
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