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Open Access Academic Papers from Research Square

2 results found
Article under-review

Sex influences gliovascular unit assembly and function in the developing mouse brain

Martine Cohen-Salmon, Lucie Lemale, Myriam Abioui-Mourgues, Rodrigo Alvear-Perez, Marina Rubio, Denis Vivien, Mathilde Becmeur-Lefebvre, Tristan Hourcade, Anne-Cécile Boulay, Barbara Delaunay-Piednoir

The gliovascular unit (GVU), a specialized interface between the brain and the vascular system, assembles and matures after birth and establishes essential homeostatic functions, including blood–brain...

Nature Portfolio 2026-04-22 rs-9313012
Gliovascular unit Sex Male Female Brain Development Vessel Astrocyte Pericyte Vascular smooth muscle cell Fibroblast Macrophage Cerebral blood flow Transcriptome
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Research Article under-review

Single-Cell and Spatial Transcriptomics Identify Astrocyte Regulation of the Microenvironment and Prognosis in High-Grade Gliomas

Chang Ge, Wenjie Zhang, Pengcheng Zhang, Jingxuan Xu

Background: High-grade glioma is a highly malignant primary tumor of the central nervous system characterized by a poor clinical prognosis. The regulatory mechanisms of astrocytes within its TME are n...

European Journal of Medical Research 2026-04-21 rs-9156282
High-grade glioma Astrocytes Tumor microenvironment Prognostic marker Immune infiltration Cell-cell communication
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