47 results found

Tianzhu Shen, Hongfei Shen, Yun Kong, Weidong Qiang, Xinwei Yu, Jiaping Wang

Apurinic/apyrimidinic endonuclease 1 (APE1) is a key enzyme in the base excision repair (BER) pathway, and its aberrant overexpression is closely associated with poor prognosis, enhanced invasiveness,...

Scientific Reports 2026-04-20 rs-9308995
APE1 virtual screening molecular docking molecular dynamics simulation MM/GBSA anticancer drug discovery

Murat Uçar, Nureddin Raym, Uğur Soy, Erkan Karadağ, Murat Topçuoğlu, Ali Akkoç

Purpose To evaluate the prognostic value of preoperative hemoglobin-lymphocyte-neutrophil ratio (HLNR) and hemoglobin-lymphocyte-platelet ratio (HLPR) for predicting tumor recurrence at control cystos...

SN Comprehensive Clinical Medicine 2026-04-20 rs-9342974
Hematologic tests Prognosis Transitional Cell Carcinoma Urinary Bladder Neoplasms

Mohan Su, can Cao, fulin sun, Liangqian jiang, Fanghao Yang, Huhu Zhang, Xiaoze Zhang, Ruixuan Wang, Ziyuan Wen, chunjuan yu, Yiming Wang, Lina Yang, Zhe Zhang, bing li

Overcoming oxidative stress is a critical mechanism by which breast cancer cells sustain malignant progression and therapeutic resistance. However, the specific regulatory networks governing this adap...

Cancer Cell International 2026-04-20 rs-9167161
Breast cancer TRIM45 p62 Ubiquitination Keap1/Nrf2 pathway oxidative stress IGF-1R 

Keiichiro Ryujin, Tetsuro Kawazoe, Yasuo Tsuda, Kensuke Kudou, Tomonori Nakanoko, Mitsuhiko Ota, Koji Ando, Eiji Oki, Tomoharu Yoshizumi

Purpose Preoperative nutritional and immunological status is closely associated with postoperative outcomes in gastric cancer. Although osteopenia and sarcopenia have been reported as prognostic facto...

Langenbeck's Archives of Surgery 2026-04-20 rs-9331253
metabolic bone diseases prognosis stomach neoplasms sarcopenia osteopenia

Qiqiao Chen, Yuhao Wu, XiaoWen Li, Shijiao Nie

Background While left-sided colon cancer (LCC) is distinct from right-sided disease, its internal heterogeneity is poorly understood. This study compares prognosis and molecular features between sigmo...

Discover Oncology 2026-04-20 rs-9201659
Left-sided colorectal cancer subtypes Sigmoid colon cancer prognosis Immune infiltration heterogeneity SEER-TCGA integrated modeling

Patrick Kierkegaard, Bowen Su, Hilary Stobart, Lesley Stephen, Szeyi Ng, Lucy Kilburn, Charlotte E. Coles

Background Patient-initiated follow-up within personalised stratified follow-up replaces some routine appointments with supported self-management and a route back to specialist care or relevant suppor...

International Journal for Equity in Health 2026-04-20 rs-9162255
Breast cancer survivorship health equity patient‑initiated follow‑up administrative burden navigation access to care NHS qualitative research

Atantra Das Gupta

Traditional approaches to anticancer dosing typically rely on fixed protocols that often overlook how patients respond differently to treatment. This can limit both effectiveness and safety. In this w...

Research Square 2026-04-20 rs-9411956
digital twin antineoplastic drug delivery reinforcement learning PBPK modeling precision oncology pharmacokinetics theragnostic deep Q-network
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