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Open Access Academic Papers from Research Square

3 results found
Article under-review

Conserved Cell-Type-Specific Transcriptomic Networks and Regulatory Programs Underlie Alcohol Dependence Across Mouse and Human

Nihal Salem, Anna Warden, Amanda Roberts, Marisa Roberto, R. Dayne Mayfield

Alcohol use disorder (AUD) is a complex polygenic disease. Rodent models of alcohol dependence have been instrumental in modeling various aspects of dependence. Single-nucleus transcriptomics has enab...

Translational Psychiatry 2026-04-21 rs-9417955
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Article under-review

A novel high-order compact finite difference scheme in space and time for solving the generalized Rosenau-KdV-RLW equation

Yanling Chen, Xiaojia Yang, Lili Wu, Yingnan Qi

In the high-accuracy numerical solution of the generalized Rosenau-KdV-RLW equation, the mismatch of the temporal and spatial accuracy orders often forces the calculation to adopt a fine grid to balan...

Scientific Reports 2026-04-21 rs-9200623
Generalized Rosenau-KdV-RLW equation Spatiotemporal fourth-order accuracy Compact finite difference method Conserved Stable
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Research Article posted

A conserved 8-gene epithelial barrier signature spatially quantifies immune exclusion across cancers and predicts immunotherapy outcome independent of HPV status

Tan Haosheng, Yu Dapeng, Jiao lianghe

Background Tumor epithelial barriers physically impede immune cell infiltration, causing immune exclusion and resistance to immune checkpoint inhibitors (ICIs). However, a simple, spatially quantifiab...

Research Square 2026-04-21 rs-9472940
epithelial barrier signature spatial transcriptomics immune exclusion immunotherapy outcome
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