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Open Access Academic Papers from Research Square

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Article under-review

Early nigrostriatal synaptic dysfunction underlies prodromal non-motor symptoms preceding dopaminergic neurodegeneration in an MPTP mouse model of Parkinson’s disease

Manasvi Chopra, Aravinthan Sekar, Albert Stezin, Rehab Hussain, Shobha Anilkumar, Sandeep K Barodia, Hariprasath Ragupathy, Shweta Ramdas, Latha Diwakar

Parkinson’s disease (PD) is characterized by progressive degeneration of nigrostriatal dopaminergic neurons; however, non-motor symptoms frequently emerge years before the onset of classical motor def...

npj Parkinson's Disease 2026-04-20 rs-9331850
Parkinson's disease MPTP Non-motor symptoms Nigro-striatal pathway Dopaminergic degeneration Serotonin transporter Alpha-Synuclein
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