998 results found

Shenkuang Wu, Siyuan Zhang, Xuanda Wu

Active learning is appealing for low-label ADME modeling, but its value under scaffold split remains difficult to interpret because acquisition rules are often compared under changing representations,...

Journal of Computer-Aided Molecular Design 2026-04-22 rs-9310145
ADME classification active learning scaffold split learning efficiency molecular representation acquisition benchmarking

Jiangyang Li, Xianfeng Lu, Shuai Yue, Ruyi Hang, Xiaoyan Dai, Xunjie Kuang, Wei Guo, Zhou Huang, Yanli Xiong, Mengxia Li

Non-small cell lung cancer (NSCLC) patients carrying HER2 20ins exon 20 insertion (HER2 20ins) are poorly respond to conventional therapies and pan HER inhibitors. Trastuzumab Deruxtecan (T-DXd) has b...

Scientific Reports 2026-04-22 rs-8854444
HER2 (ERBB2) NSCLC Deruxtecan (T-DXd DS-8201) Genomic instability Immune microenvironment

Chien-Rui Lai, Ying Chen, Tzu-Min Chen, Yu-Ling Tsai, Wen-Chiuan Tsai, Sheng-Tang Wu, Chien-Chang Kao

Background Bladder cancer (BC) is a common urologic malignancy with high recurrence and progression rates, and outcomes for advanced disease remain poor. Peroxisome proliferator-activated receptor gam...

Cancer Cell International 2026-04-22 rs-9134319
PPARγ 15d-PGJ2 cisplatin mitochondria ROS bladder cancer apoptosis mitochondria membrane potential

Hayato Takei, Tetsuro Ohba, Toshiyuki Shimono, Nobuki Tanaka, Kotaro Oda, Kai Mizukami, Go Goto, Hiroshi Yokomichi, Hirotaka Haro

Purpose To identify preoperative and early postoperative spinopelvic parameters associated with loss of global sagittal correction after short-segment lumbar fusion in patients with preoperative sagit...

European Journal of Orthopaedic Surgery & Traumatology 2026-04-22 rs-9365751
lumbar fusion sagittal vertical axis lumbar lordosis lordosis distribution index sagittal alignment

Izidor Mlakar, Satja Mulej Bratec, Valentino Šafran, Ana Milošič, Matic Kadiš, Hojka Gregorič Kumperščak, Sara Močnik, Žan Smogavc, Zouhair Haddi, Urška Smrke

Background: Anxiety disorders, depression, and borderline personality disorder often emerge during adolescence, yet early psychiatric assessment remains challenging because conventional interviews are...

BMC Psychiatry 2026-04-22 rs-9204470
digital phenotyping adolescent mental health anxiety disorders depression borderline personality disorder chatbot virtual agent mental health screening

Fangli Liu, Yufen Xue, Jiachi Wang, Tengteng Kang, Cunzhe Tong, Jing Liu, Jiexin Deng

Background Motor dysfunction caused by stroke not only directly impairs physiological functions but also exerts a negative impact on psychological well-being. Adherence to functional exercises is crit...

BMC Nursing 2026-04-22 rs-9146399
Stroke Illness perception Sense of coherence Self-regulatory fatigue Functional exercise adherence Mediating effect

Jecha Jecha, Hayfa Nassor

Generative artificial intelligence (GenAI) is entering higher education systems across Africa at a pace that outstrips institutional preparedness, yet empirical evidence from small, resource-constrain...

Research Square 2026-04-22 rs-9479399
generative AI higher education PLS-SEM technology adoption readiness preparedness mixed methods Zanzibar Africa

Sofia Valencia Ruiz, Marianne Øverlie, Amanda Bergren, Ingunn Risnes Hellings

Background Lyme borreliosis (LB), caused by Borrelia burgdorferi, is an emerging concern in human medicine, and is a controversial topic in equine medicine. Neuroborreliosis (NB), a neurologic manifes...

Research Square 2026-04-22 rs-9209934
Borrelia cerebrospinal fluid doxycycline equine neuroinfection

Yan Peng, Mengqi Li, Huaiwei Zhang

To characterize microbial distribution and antimicrobial susceptibility profiles in purulent specimens from pediatric acute appendicitis, guiding evidence-based antibiotic therapy optimization. In thi...

Research Square 2026-04-22 rs-9428869
Microbial distribution Antimicrobial susceptibility Antibiotic resistance Empirical antibiotic therapy

Ekram Hadi alaskaree

This study presents a comprehensive heat transfer and energy–exergy analysis of an integrated anaerobic digestion–Sabatier system for renewable methane production. The proposed configuration combines ...

Waste and Biomass Valorization 2026-04-22 rs-9056297
Anaerobic digestion Energy–exergy analysis Heat transfer Renewable methane Sabatier methanation Waste valorization
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