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Open Access Academic Papers from Research Square

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Research Article under-review

Physiologically Based Pharmacokinetic Modeling to Predict Human Pharmacokinetics of a Novel Mithramycin Analog for Ewing Sarcoma

Kumar Kulldeep Niloy, Jamie Horn, Nazmul Hasan Bhuiyan, Suhas S. Bhosale, Khaled A. Shaaban, Thomas E. Prisinzano, Jon S. Thorson, Jurgen Rohr, Markos Leggas

Purpose To develop and verify a physiologically based pharmacokinetic (PBPK) modeling strategy for mithramycin (MTM) and its analog, MTMSA-Trp, with the aim of projecting first-in-human plasma pharmac...

Cancer Chemotherapy and Pharmacology 2026-04-23 rs-9488905
Physiologically based pharmacokinetic model First-in-human dose prediction Interspecies scaling Mithramycin analog Ewing sarcoma
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