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Research Article posted

Mechanistic Modeling of Stress-Induced Glucose Dysregulation: Calibrating a Coupled HPA-Metabolic Framework to the UK Biobank

Rezo Getsadze, Qiziyi Cao, Shivam Kumar, Vivek M. Sheraton

Type 2 Diabetes (T2D) is a heterogeneous metabolic disorder driven by the interplay between endocrine stress and glucose regulation. We adapt an 18-variable ordinary differential equation (ODE) model ...

Research Square 2026-04-22 rs-9475176
Mechanistic Modeling HPA Axis Type 2 Diabetes UK Biobank Individualized Calibration
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