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Open Access Academic Papers from Research Square

2 results found
Research Article posted

Single-Run RP-HPLC Method for Comprehensive Separation of Nine Bisoprolol Fumarate Impurities Aligned with USP and EP

Monika Trivedi

A novel, efficient reverse phase high performance liquid chromatography (RP-HPLC) method was developed and validated for the complete separation of nine impurities related to Bisoprolol fumarate activ...

Research Square 2026-04-21 rs-9461723
Bisoprolol fumarate Method validation HPLC Related substances
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Short Report under-review

Validated HPLC Method for Simultaneous Determination of Metronidazole Benzoate, Diloxanide Furoate, and Paraben Preservatives in Combined Formulations

Ibrahim Sharhan, Wafa M. Al‑Madhagi, Ahmed M. Sabati, Ammar AL-Farga

Objective: To develop and validate a simple, precise, and stability-indicating reversed-phase high-performance liquid chromatographic (RP-HPLC) method for the simultaneous determination of metronidazo...

BMC Research Notes 2026-04-20 rs-9304498
RP-HPLC validation Metronidazole Benzoate Diloxanide Furoate ICH
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