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Open Access Academic Papers from Research Square

2 results found
Research Article under-review

Single-Cell and Spatial Transcriptomics Identify Astrocyte Regulation of the Microenvironment and Prognosis in High-Grade Gliomas

Chang Ge, Wenjie Zhang, Pengcheng Zhang, Jingxuan Xu

Background: High-grade glioma is a highly malignant primary tumor of the central nervous system characterized by a poor clinical prognosis. The regulatory mechanisms of astrocytes within its TME are n...

European Journal of Medical Research 2026-04-21 rs-9156282
High-grade glioma Astrocytes Tumor microenvironment Prognostic marker Immune infiltration Cell-cell communication
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Research Article under-review

Divergent molecular landscapes and immune microenvironments drive prognostic differences within left-sided colon cancer

Qiqiao Chen, Yuhao Wu, XiaoWen Li, Shijiao Nie

Background While left-sided colon cancer (LCC) is distinct from right-sided disease, its internal heterogeneity is poorly understood. This study compares prognosis and molecular features between sigmo...

Discover Oncology 2026-04-20 rs-9201659
Left-sided colorectal cancer subtypes Sigmoid colon cancer prognosis Immune infiltration heterogeneity SEER-TCGA integrated modeling
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