4 results found

Jiangyang Li, Xianfeng Lu, Shuai Yue, Ruyi Hang, Xiaoyan Dai, Xunjie Kuang, Wei Guo, Zhou Huang, Yanli Xiong, Mengxia Li

Non-small cell lung cancer (NSCLC) patients carrying HER2 20ins exon 20 insertion (HER2 20ins) are poorly respond to conventional therapies and pan HER inhibitors. Trastuzumab Deruxtecan (T-DXd) has b...

Scientific Reports 2026-04-22 rs-8854444
HER2 (ERBB2) NSCLC Deruxtecan (T-DXd DS-8201) Genomic instability Immune microenvironment

Wang Zhe, Xiong Yan

Radiotherapy (RT) is integral to the management of head and neck squamous cell carcinoma (HNSCC), yet no validated biomarker exists to predict which patients benefit most. Lactylation, a metabolic pos...

Discover Oncology 2026-04-21 rs-9250884
Head and neck squamous cell carcinoma Lactylation Radiosensitivity Predictive biomarker Tumor immune microenvironment

Yanchu Tong, Wenkui Chen, Shun Deng, Lu Qin

Objective: To investigate the role of DISP3 in thyroid cancer (TC) progression and its modulation of the tumor immune microenvironment. Methods: Bioinformatics analyzed DISP3 expression and its progno...

Research Square 2026-04-21 rs-9394485
DISP3 Thyroid cancer Tumor immune microenvironment Macrophage polarization dendritic cell

Qiqiao Chen, Yuhao Wu, XiaoWen Li, Shijiao Nie

Background While left-sided colon cancer (LCC) is distinct from right-sided disease, its internal heterogeneity is poorly understood. This study compares prognosis and molecular features between sigmo...

Discover Oncology 2026-04-20 rs-9201659
Left-sided colorectal cancer subtypes Sigmoid colon cancer prognosis Immune infiltration heterogeneity SEER-TCGA integrated modeling
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