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Endogenous Incretin Insufficiency in Obesity: Etiological Defect or Metabolic Maladaptation?

Luís Jesuíno de Oliveira Andrade, Gabriela Correia Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Osmário Jorge de Mattos Salles, Luís Matos de Oliveira

Introduction: Obesity is associated with measurably attenuated postprandial incretin responses, characterized by blunted glucagon-like peptide-1 (GLP-1) secretion and functional resistance to glucose-...

Research Square 2026-04-21 rs-9453154
Enteroendocrine dysfunction GLP-1 secretion Incretin resistance Metabolic maladaptation
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