43 results found

Gonçalo da Silva, Konstantin Barylyuk, Tasso Miliotis, Karin Jennbacken, Maria Ryaboshapkina

Endogenous cyanide has recently been identified in mammals and implicated in regulating mitochondrial function and the response to hypoxia. It is hypothesized to act as a gasotransmitter with function...

Research Square 2026-04-21 rs-9472761
Proteomics Cyanylation MASLD

HANG WANG, HASSAN ALLI, Nurhanisah Mohd Hawari

This study introduces a Human–AI Co-Creation Design (HACD) Framework aimed at enhancing customer experience in the packaging design of traditional cultural products. Although artificial intelligence (...

Scientific Reports 2026-04-21 rs-9002708
AI–Human Co-creation Cultural semiotics Customer Experience Design aesthetics Emotional resonance Packaging design Traditional cultural products

Dun Liu, Aierken Rehemutula, Zihao Chen, Yu Si, Hongyu Zhou, LI LI

Purpose To systematically evaluate the clinical efficacy and safety of antibiotic-loaded calcium sulfate (ALCS) as a local antibiotic delivery system for the treatment of osteomyelitis in adult patien...

Research Square 2026-04-21 rs-9416548
Osteomyelitis Antibiotic-loaded calcium sulfate Local antibiotic delivery Meta-analysis Systematic review Infection eradication Bone healing Biodegradable carrier

Sara Alferjani, Mohamed HADi Mohamed Abdelhamid, Amal Benkorah

Background: Antiretroviral stock-outs in conflict-affected regions like Libya disrupt essential HIV treatment, risking viral suppression and health outcomes. However, the specific clinical impact of t...

Research Square 2026-04-21 rs-9451632
HIV antiretroviral stock-outs viral load suppression adherence co-infection digital health Libya

Akis Kourtis, Achilleas Economopoulos, George Xilouris, Evangelos Markakis

The proliferation of Internet of Things (IoT) devices operating in swarm-like formations—from autonomous device fleets to federated service networks— demands a computing continuum that spans edge node...

Discover Internet of Things 2026-04-21 rs-9232592
service mesh scalability IoT-to-cloud continuum tail latency benchmarking Istio microservices sidecar proxy overhead Fortio Kubernetes cloud-native performance

Thanyaporn Tengsuttiwat, Adam Burke, Naheed Nazly Kaderbhai, Joseph Gallagher, Howbeer Muhamadali, Royston Goodacre

Introduction: Recombinant protein production is pivotal across diverse industries, necessitating efforts to enhance both quantity and quality. Objectives: We employed gas chromatography coupled with m...

Metabolomics 2026-04-21 rs-9277397
GC-MS metabolic profile recombinant protein production cytochrome b5 chemometrics

Lida-Alkisti Xenaki, Pentagiotissa Stefanatou, Leonidas Mantonakis, George Konstantakopoulos, Stratis Alexandrou, Eirini Ralli, Alex Hatzimanolis, Stefanos Dimitrakopoulos, Rigas-Filippos Soldatos, Ilias I. Vlachos, Mirjana Selakovic, Stefania Foteli, Ioannis Kosteletos, Nikos Nianiakas, Evaggelia Psara, Aggeliki Ntigridaki, Theoni-Fani Triantafyllou, Marina Voulgaraki, Konstantinos Kollias, Nikos C. Stefanis

Background: First-episode psychosis (FEP) is a critical stage in psychotic disorders, in terms of clinical and functional outcome. Deficits in facial emotion recognition and impaired clinical insight ...

BMC Psychiatry 2026-04-21 rs-9357271
first-episode psychosis facial emotion recognition insight social functioning

Serhat Atalar, Gürdal Yılmaz, Ahmet Eroğlu, İftihar Köksal

Background The optimal duration of treatment for ventilator-associated pneumonia (VAP) remains controversial. Although current guidelines recommend 7-8 days of therapy, many patients receive treatment...

BMC Anesthesiology 2026-04-20 rs-9269769
Ventilator-associated pneumonia short-course therapy individualized treatment antibiotic duration procalcitonin PaO₂/FiO₂ ratio antimicrobial stewardship

Chidiebele Petronilla Ojukwu, Okolo Chukwunonyelum Judith, Fatai Kadiree Ekundayo, Adaeze I Onyekwelu, Chiedozie Eleje, Juliet Ekowa

Background Physical activity (PA) is essential for children’s physical, cognitive, and psychosocial development; however, many children do not meet recommended PA levels, particularly in low- and midd...

BMC Public Health 2026-04-20 rs-8921294
Children Physical activity Parental perceptions School-based physical activity Community participation Nigeria

Byeongsoo

Background. Flux balance analysis (FBA) is widely used to simulate gene essentiality in genome-scale metabolic models (GEMs), and several studies have proposed using FBA-based combination simulations ...

Research Square 2026-04-20 rs-9398278
flux balance analysis antibiotic synergy linear programming machine learning genome-scale metabolic model drug combination ESKAPE Bliss independence
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