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Open Access Academic Papers from Research Square

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Research Article under-review

Low-coverage whole-genome sequencing of plasma cell-free DNA to predict treatment response and progression-free survival in advanced NSCLC receiving EGFR-tyrosine kinase inhibitors or chemotherapy: A pilot prospective study

Pitithat Puranachot, Thivaratana Sinthuwiwat, Priyavudh Herabutya, Kanthida Jangyubol, Bongkod Petcharat, Jutamas Yimnoon, Jitsopin Phadungsut, Chayanee Samdaengpan, Chumut Phanthunane

Background: Accurately predicting treatment outcomes in patients with advanced non-small cell lung cancer (NSCLC) remains a significant clinical challenge. While circulating tumor DNA (ctDNA) within p...

BMC Personalized Medicine 2026-04-21 rs-9258115
Liquid biopsy monitoring Cell-free DNA Non-small cell lung cancer Progression-free survival Copy-number alterations cfDNA fragmentation Low-coverage whole-genome sequencing
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