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Biological Sciences - Article posted

Temporal integration of systemic signals governs biological size and phase transitions

sumihare noji, yoshiyasu ishimaru, Tetsuya Bando, Akiyoshi Tominaga, Shintaro Inoue, Takahito Watanabe, Hideyo Ohuchi, Kenji Tomioka, taro mito

For over a century, developmental phase transitions such as metamorphosis and puberty have been presumed to be triggered by instantaneous spatial size thresholds1-9. Here we overturn this paradigm, de...

Research Square 2026-04-22 rs-9459668
Size determination Myoglianin Myostatin GDF11 Epigenetic Integration Clock Area-Constancy Rule of Epigenetics Allometry
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