3 results found

Rezo Getsadze, Qiziyi Cao, Shivam Kumar, Vivek M. Sheraton

Type 2 Diabetes (T2D) is a heterogeneous metabolic disorder driven by the interplay between endocrine stress and glucose regulation. We adapt an 18-variable ordinary differential equation (ODE) model ...

Research Square 2026-04-22 rs-9475176
Mechanistic Modeling HPA Axis Type 2 Diabetes UK Biobank Individualized Calibration

Joanna Ostrowska, Ewa Kobos, Mariola Pietrzak, Agata Szymczak, Katarzyna Wiktorzak, Marta M. Pisano-González

Background Type 2 diabetes remains a major public health challenge, requiring lifelong management. Structured lifestyle-based interventions are increasingly recognised for their role in supporting sel...

Scientific Reports 2026-04-21 rs-9169658
type 2 diabetes lifestyle self-monitoring of blood glucose (SMBG) continuous glucose monitoring (CGM) HbA1c weight loss

Xuan Gao, Robin Lengton, Jenny A. Visser, James McLaren, Naveed Sattar, Dilys J. Freeman, Mariëtte R. Boon, Jason M.R. Gill

Purpose Adipocyte glucocorticoid (GC) signalling influences lipid storage and insulin sensitivity, and South Asians develop insulin resistance at lower BMI than White Europeans. We tested whether earl...

Metabologia 2026-04-20 rs-9199966
Adipocyte Ethnicity FKBP5 GILZ Glucocorticoid signalling Insulin South Asian Subcutaneous adipose tissue Type 2 diabetes Weight gain
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