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Open Access Academic Papers from Research Square

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Article under-review

VPS11 Promotes Ubiquitination-Dependent Degradation of TFEB to Orchestrate Autophagy-Lysosome Pathway Homeostasis and Anti-tumor Efficacy

Huiqing Yuan, Huanmin Niu, Xiaoxue Zheng, Yuhao Sun, Qi Sun, Qiqi Lu, Mengqi Jia

The autophagy-lysosome pathway, governed by transcription factor EB (TFEB), is critical in cellular degradation and signal transduction. Dysregulation of this pathway or TFEB contributes to aging, tum...

Oncogene 2026-04-23 rs-9323678
VPS11 TFEB MHC-Ⅰ ubiquitin autolysosome
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