2 results found

Chien-Rui Lai, Ying Chen, Tzu-Min Chen, Yu-Ling Tsai, Wen-Chiuan Tsai, Sheng-Tang Wu, Chien-Chang Kao

Background Bladder cancer (BC) is a common urologic malignancy with high recurrence and progression rates, and outcomes for advanced disease remain poor. Peroxisome proliferator-activated receptor gam...

Cancer Cell International 2026-04-22 rs-9134319
PPARγ 15d-PGJ2 cisplatin mitochondria ROS bladder cancer apoptosis mitochondria membrane potential

Mads Gyrd-Hansen, John Rizk, Frederik Timmermann, Wenxin Lyu, Kit Lee, Majken Kjær, Miriam Beichler, Berthe Fiil, Malin Jessen, Giulia Franciosa, Jesper Olsen, Max Sauerland, Rune Damgaard, Dominik Priesmann

Met1-linked ubiquitin (Met1-Ub) assembled by LUBAC crucially regulates immune receptor signalling. However, the regulation of LUBAC’s function remains widely debated. Here, we reveal that the interact...

Nature Portfolio 2026-04-22 rs-5519483
LUBAC PUB domain Met1-linked ubiquitin OTULIN CYLD SPATA2 TNF immune receptor inflammation cell death immunology
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