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Article under-review

Chemical modification of pyrroloquinoline quinone identifies a monomethyl ester derivative that enhances DUOX activation and causes lethality in C. elegans

Hiroyuki Sasakura, Moribe Hiroki, Kazuto Ikemoto, Masashi Ikeno, Yuki Morioka, Yuka Takeuchi, Kosei Takeuchi

Pyrroloquinoline quinone (PQQ) is a multifunctional natural coenzyme that plays important roles in innate immunity, nutritional physiology, and redox biology, including the activation of dual oxidases...

Scientific Reports 2026-04-22 rs-9310397
Pyrroloquinoline quinone (PQQ) chemical modification monomethyl ester dual oxidase (DUOX) reactive oxygen species Caenorhabditis elegans
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