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Open Access Academic Papers from Research Square

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Research Article posted

A conserved 8-gene epithelial barrier signature spatially quantifies immune exclusion across cancers and predicts immunotherapy outcome independent of HPV status

Tan Haosheng, Yu Dapeng, Jiao lianghe

Background Tumor epithelial barriers physically impede immune cell infiltration, causing immune exclusion and resistance to immune checkpoint inhibitors (ICIs). However, a simple, spatially quantifiab...

Research Square 2026-04-21 rs-9472940
epithelial barrier signature spatial transcriptomics immune exclusion immunotherapy outcome
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