3 results found

Vaishali Chaurasiya, Luyang Li, Aina Lluch, Ana Fernández-Sánchez, Jukka Harju, Dan Duc Pham, Sanni Perttunen, Salla Keskitalo, Markku Varjosalo, Kirsi H. Pietiläinen, P.A. Nidhina Haridas, José-Maria Moreno-Navarrete, José I. Rodríguez-Hermosa, Encarna Piedrafita-Serra, Asha Kar, Päivi Pajukanta, Markku Laakso, Ville Männistö, Jussi Pihlajamäki, Minna U. Kaikkonen, Gema Frühbeck, Oriol A. Rangel-Zúñiga, Francisco José Tinahones, Carlos Dieguez, Ralph Burkhardt, Marcus Höring, Gerhard Liebisch, Johanna Pörschke, María Gómez-Serrano, Johannes Graumann, Witold Szymanski, José-Manuel Fernández-Real, You Zhou, Vesa Olkkonen, Francisco Ortega

Obesity-related metabolic disease is linked to impaired adipose tissue function, but the underlying molecular programs are difficult to assign to specific adipose-resident cell types, to mechanistical...

Research Square 2026-04-23 rs-9485802
Adipose tissue adipocyte endothelial cell proteomics lipidomics meta-inflammation obesity weight loss

Mads Gyrd-Hansen, John Rizk, Frederik Timmermann, Wenxin Lyu, Kit Lee, Majken Kjær, Miriam Beichler, Berthe Fiil, Malin Jessen, Giulia Franciosa, Jesper Olsen, Max Sauerland, Rune Damgaard, Dominik Priesmann

Met1-linked ubiquitin (Met1-Ub) assembled by LUBAC crucially regulates immune receptor signalling. However, the regulation of LUBAC’s function remains widely debated. Here, we reveal that the interact...

Nature Portfolio 2026-04-22 rs-5519483
LUBAC PUB domain Met1-linked ubiquitin OTULIN CYLD SPATA2 TNF immune receptor inflammation cell death immunology

Yumeng Mao, Irineos Papakyriacou, Yonglin Lu, Liam Alford

Acute myeloid leukemia is an aggressive hematological disease, where cancer cells down-regulate antigen presentation and immune-stimulatory molecules. Here, we show that genetic deletion of protein ne...

Leukemia 2026-04-21 rs-9399910
Protein neddylation Toll-like receptors Myeloid cells Leukemia Tumor Immunology
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