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Open Access Academic Papers from Research Square

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Research Article posted

Identification of Cancer-Type-Specific CRISPR Targets Using DepMap Dependency Data

Li Ranfei, Wang Sirui, Yang Qiying

CRISPR-Cas9 screening enables systematic identification of gene dependencies across diverse cancer cell lines. However, distinguishing lineage-specific vulnerabilities from broadly essential genes rem...

Research Square 2026-04-21 rs-9463556
CRISPR-Cas9 DepMap cancer dependency bioinformatics lineage-specific targets nucleotide metabolism
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