3 results found

Jiangyang Li, Xianfeng Lu, Shuai Yue, Ruyi Hang, Xiaoyan Dai, Xunjie Kuang, Wei Guo, Zhou Huang, Yanli Xiong, Mengxia Li

Non-small cell lung cancer (NSCLC) patients carrying HER2 20ins exon 20 insertion (HER2 20ins) are poorly respond to conventional therapies and pan HER inhibitors. Trastuzumab Deruxtecan (T-DXd) has b...

Scientific Reports 2026-04-22 rs-8854444
HER2 (ERBB2) NSCLC Deruxtecan (T-DXd DS-8201) Genomic instability Immune microenvironment

Riya Albert, Joshua Thomas, Navid Sadeghi, Sangeetha Reddy, Glenda Delgado, Heather McArthur, Samira Syed, Deborah Farr, Nisha Unni

Introduction Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by poor prognosis. Based on the KEYNOTE-522 trial, neoadjuvant pembrolizumab plus chemotherapy has become the s...

Breast Cancer Research and Treatment 2026-04-21 rs-9096569
tumor-infiltrating lymphocytes triple-negative breast cancer neoadjuvant therapy immunotherapy pathological complete response

Yan Ding, Juan Yu, Min Liu, Xiangyu Liu, Ling Kang, Liujing Huang, Jinze Li, Yanan Wang, Xin Xu, Min Zhao, Ping Wei, Shuangbiao Li, Zaibo Li, Yueping Liu

Background Neoadjuvant therapy (NAT) is crucial for locally advanced breast cancer, but post-NAT lymph node assessment is challenging due to histological changes. Current methods like immunohistochemi...

Breast Cancer Research 2026-04-20 rs-9159505
breast cancer neoadjuvant therapy lymph node metastasis artificial intelligence digital pathology CLAM framework
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