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Open Access Academic Papers from Research Square

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Research Article under-review

Immunogenic implications of translational readthrough modulate the association of F8 nonsense mutations with inhibitors in Hemophilia A

Maria Francesca Testa, Mirko Pinotti, Alessio Branchini, Maria Elisa Mancuso, Francesco Bernardi, Dario Balestra

Background: Among F8 mutation types, main determinants of inhibitor development after replacement therapy in Hemophilia A, nonsense mutations display wide variation in the associated risk. Molecular m...

Molecular Medicine 2026-04-23 rs-9414495
F8 PTCs Hemophilia A translational readthrough inhibitory antibody peptide MHCII affinity personalized medicine
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