SinoXiv
3
results found
Purpose To develop and verify a physiologically based pharmacokinetic (PBPK) modeling strategy for mithramycin (MTM) and its analog, MTMSA-Trp, with the aim of projecting first-in-human plasma pharmac...
Physiologically based pharmacokinetic model
First-in-human dose prediction
Interspecies scaling
Mithramycin analog
Ewing sarcoma
Background Oral administration is the preferred route for drug delivery due to convenience and patient compliance, yet its efficacy is hampered by low solubility and enzymatic degradation. Nanoparticu...
nanoparticles
oral bioavailability
drug delivery systems
pharmacokinetics
Traditional approaches to anticancer dosing typically rely on fixed protocols that often overlook how patients respond differently to treatment. This can limit both effectiveness and safety. In this w...
digital twin
antineoplastic drug delivery
reinforcement learning
PBPK modeling
precision oncology
pharmacokinetics
theragnostic
deep Q-network
