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Open Access Academic Papers from Research Square

3 results found
Research Article under-review

Biochemical and Multi-Omics Analyses Reveal Skeletal Muscle Adaptation to Chronic Low-Salinity Stress of Marine Medaka (Oryzias melastigma)

Tian-Hong Chen, Qing-Hao Zhan, Xiao-Yu Zeng, Ning-Ning Ma, Qi-Liang Li, Run-Jie Jin, Jia-Lang Zheng, Qing-Ling Zhu

Salinity fluctuations are key environmental drivers that shape physiological homeostasis in euryhaline teleosts by altering osmotic balance and energy allocation. In this study, marine medaka (Oryzias...

Fish Physiology and Biochemistry 2026-04-21 rs-9208878
salinity Oryzias melastigma skeletal muscle transcriptomics metabolomics
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Research Article under-review

Single-Cell and Spatial Transcriptomics Identify Astrocyte Regulation of the Microenvironment and Prognosis in High-Grade Gliomas

Chang Ge, Wenjie Zhang, Pengcheng Zhang, Jingxuan Xu

Background: High-grade glioma is a highly malignant primary tumor of the central nervous system characterized by a poor clinical prognosis. The regulatory mechanisms of astrocytes within its TME are n...

European Journal of Medical Research 2026-04-21 rs-9156282
High-grade glioma Astrocytes Tumor microenvironment Prognostic marker Immune infiltration Cell-cell communication
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Research Article posted

A conserved 8-gene epithelial barrier signature spatially quantifies immune exclusion across cancers and predicts immunotherapy outcome independent of HPV status

Tan Haosheng, Yu Dapeng, Jiao lianghe

Background Tumor epithelial barriers physically impede immune cell infiltration, causing immune exclusion and resistance to immune checkpoint inhibitors (ICIs). However, a simple, spatially quantifiab...

Research Square 2026-04-21 rs-9472940
epithelial barrier signature spatial transcriptomics immune exclusion immunotherapy outcome
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