Knowing the position and orientation of the surroundings relative to oneself is essential in gauging the spatial properties of the environment. We measured people's accuracy and precision in judging (a) the position (using a virtual room) and the orientation of a room (using a real room) relative to an allocentric (the surrounding real room) or egocentric (body) reference frames, and (b) the orientation of their own body. When judging the position and orientation of the room, people were generally accurate sitting in the center of it, but showed a cross-reference influence when not sitting in the center. This may indicate a 'central body position bias', i.e., a tendency to judge one's body as being at the center of any space. When judging a room's orientation, people thought an upright room was tilted relative to gravity, but their body orientation had no impact on this misperception. When judging their body orientation relative to gravity, people thought they were tilted when upright, but their perception was unaffected by the room tilt. We discuss these results in terms of the contribution of the egocentric and allocentric cues in human perception of the position and orientation of a room relative to themselves.