Background About half of both men and women have lower urinary tract symptoms, and aging is reported to have a significant impact on these symptoms. Lifestyle-related diseases such as diabetes, hypertension, and metabolic syndrome are said to be comorbidities of lower urinary tract symptoms in men, and there are reports that lower urinary tract symptoms also affect mental health, such as quality of life, depression, and anxiety symptoms. In this study, we report on the association between lower urinary tract symptoms and depressive symptoms in men using a web-based questionnaire. Methods Of the 4.5 million people registered as monitors with the Internet research company (Freeasy I-Bridge), 4,000 Japanese males without a history of smoking were selected as subjects for a questionnaire (Overactive Bladder Symptom Score; OABSS; International Consultation on Incontinence Questionnaire-Short Form; ICIQ-SF; International Prostate Symptom Score; IPSS; Quality Of Life index; IPSS International Consultation on Incontinence Questionnaire-Short Form; ICIQ-SF; International Prostate Symptom Score; IPSS; Quality Of Life index; QOL index) and depression status (OABSS, IPSS, IPSS, QOL index). All patients who responded to all items during the 2-week request period were included in the analysis, and t-tests, χ Square test, and One factor ANOVA tests were performed for urinary symptoms and depressive symptoms. Results A survey was conducted on 4,000 Japanese men, with 2,658 responses received, and the average age was 46.4 years. The average age decreased in correlation with the severity of QIDS-J (p<0.001). No significant difference was observed in OABSS scores based on QIDS-J severity (p=0.245), but both ICIQ-SF and IPSS scores were significantly higher as QIDS-J severity increased (both p<0.001). The OAB diagnosis rate showed a significant difference according to the severity of QIDS-J (p=0.008), but the UUI diagnosis rate did not show a significant difference according to the severity of QIDS-J (p=0.500). Additionally, a separate analysis was conducted for the 20–40 age group, and while OABSS did not show a significant difference based on QIDS-J severity (p=0.7358), ICIQ-SF and IPSS did show a significant difference based on QIDS-J severity (both p<0.001). The OAB diagnosis rate and UUI diagnosis rate both showed no significant difference based on the severity of QIDS-J (p=0.708 and p=0.621, respectively). Conclusions The ICIQ-SF and IPSS tended to be higher with more depressive symptoms for both all ages and ages 20-40, but no association with OABSS was found.