471 results found

Saifeldin A. Hassan, Jaynell Hannah R. Atmosfera, Yasmeen Aboussaf

Tracheal neoplasms are rare, accounting for a very small proportion of respiratory tract malignancies. Tracheal chondrosarcoma is an exceptionally uncommon tumor, with fewer than 40 cases reported in ...

Research Square 2026-04-21 rs-9388471
Bronchoscopy Chondrosarcoma Extra-luminal Tracheal neoplasms

Solomon Tessega

Background: Cervical cytology–histology correlation (CHC) is a key component of quality assurance (QA) in gynecologic cytopathology, enabling assessment of diagnostic concordance and identification of...

Research Square 2026-04-21 rs-9460175

Sara Alferjani, Mohamed HADi Mohamed Abdelhamid, Amal Benkorah

Background: Antiretroviral stock-outs in conflict-affected regions like Libya disrupt essential HIV treatment, risking viral suppression and health outcomes. However, the specific clinical impact of t...

Research Square 2026-04-21 rs-9451632
HIV antiretroviral stock-outs viral load suppression adherence co-infection digital health Libya

Carmen Fernández-González, Hichem Saoudi, Celia Mazariegos-Iglesias, Beatriz de la Calle, Francisco Javier Díaz-Pernas, Míriam Antón-Rodríguez, David González-Ortega, Daniel Iordanov, Mario Martínez-Zarzuela

Precise characterization of gait patterns is essential for the clinical assessment of motor disorders, such as cerebral palsy (CP) and idiopathic toe walking (ITW). While laboratory-based motion captu...

Research Square 2026-04-21 rs-9471086

Margareth C. Ozelo, Bruna Webler, Julia Lima, Mariana Alves, Ana Karolina de Nunes, Ana Dantas, Rodrigo F. Alexandre, Daniela V. Pachito, Ieda Solange de Souza Pinto

Background: Despite therapeutic advances, important gaps persist in hemophilia care within public healthcare systems in middle-income countries. In Brazil, universal access to prophylaxis is ensured t...

Research Square 2026-04-21 rs-9471111
Hemophilia A Hemophilia B Needs Assessment Medication adherence Delphi Technique Brazil

Tan Haosheng, Yu Dapeng, Jiao lianghe

Background Tumor epithelial barriers physically impede immune cell infiltration, causing immune exclusion and resistance to immune checkpoint inhibitors (ICIs). However, a simple, spatially quantifiab...

Research Square 2026-04-21 rs-9472940
epithelial barrier signature spatial transcriptomics immune exclusion immunotherapy outcome

S Sukesh Gautam, Darshini Adhinathan, Sai Rithika Reddy, Namrita Jeyaraj

Background: Acanthosis nigricans (AN) is a dermatological condition characterised by hyperpigmented, velvety, thickened skin, primarily affecting intertriginous areas such as the neck, axillae, and gr...

Research Square 2026-04-21 rs-9477098
Acanthosis nigricans chemical peels trichloroacetic acid glycolic acid fractional CO2 laser microneedling post-inflammatory hyperpigmentation

Jun Yu, Jie Huang, Qinghua Ma, Yanyu Chen, Xinyue Huang, Jian Chen

Background: Sarcopenia represents a highly prevalent and prognostically detrimental complication in patients with bone tumors. Its progressive and dynamic nature hinders early intervention and amplifi...

BMC Musculoskeletal Disorders 2026-04-21 rs-9305260
Bone Neoplasms Sarcopenia Risk Assessment Predictive Model Nomogram Prognosis

Lianbao Kong, Zhiwen Feng, Qingpeng Lv, Kuan Li, Guoqing Liu, Chao Yang, Wenzhou Ding, Deming Zhu, Wenhu Zhao, Yanzhi Feng, Xiangyu Ling, Xiangyu Qu

CircRNAs are critically involved in the progression of numerous cancers, including hepatocellular carcinoma (HCC). While circCOPA has been reported to function as a tumor suppressor in glioblastoma, i...

Cancer Gene Therapy 2026-04-21 rs-9321668
circRNA hepatocellular carcinoma RNA-binding protein mRNA stability

Susan Logue, Gideon Ong, Masozi Palata, Suraj Shaji, Joel Pearson

The Unfolded Protein Response (UPR) is a conserved network of signaling pathways controlled by the Endoplasmic Reticulum (ER) anchored stress sensors IRE1, PERK and ATF6. The UPR’s primary function is...

Cell Death & Disease 2026-04-21 rs-9373070
Endoplasmic Reticulum Stress Unfolded Protein Response ATF6 IRE1
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