Phase II trial of Pembrolizumab and Lenvatinib in Advanced Neuroendocrine Prostate Cancer (PLANE-PC)
Background: Effective therapies remain a currently unmet need for neuroendocrine prostate cancer (NEPC). Preclinical synergy in small cell cancer, and clinical tolerability led to the conduct of a mul...
Large language models are increasingly used in clinical medicine, but their reliance on cloud servers conflicts with patient-privacy requirements and excludes resource-limited healthcare systems. Smal...
Cross-linking mass spectrometry (XL-MS) is a technique for investigating protein-protein interactions (PPIs) and protein structures. In the realm of biology, post-translational modifications (PTMs) pl...
Restoring haptic feedback remains a major challenge in robot-assisted minimally invasive surgery (RMIS), especially for localizing subsurface tumors and estimating their depth. This paper presents a c...
To overcome shortcomings that rocking steel frame structures require numerous internal self-centering joints and corresponding rocking interfaces, and reducing the special design requirements for infi...
Postnatal depression (PND) increases the risk of neurodevelopmental impairments in offspring, yet the underlying mechanisms remain elusive. Here, we identify an intergenerational signaling pathway thr...
Identifying the sources of foodborne diseases is crucial for guiding national food safety strategies and supporting policies that promote safe and sustainable diets. We present global estimates of the...
Rice employs sophisticated and multilayered regulatory networks to precisely modulate innate immune responses against diverse pathogens. Although post-transcriptional control has emerged as a vital la...
The bottom-up synthesis of three-dimensional chiral metallic nanostructures without molecular chiral ligands remains a fundamental challenge. Here we report a template-confined, ligand-free strategy p...
This paper presents a systematic simulation-based framework for comparing the structural performance and energy efficiency of robotic arm links fabricated from Aluminium 6061-T6 and Carbon Fiber Reinf...
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