998 results found

Matei mselle, Vickfarajaeli Daudi

Background Neonatal sepsis caused by Klebsiella pneumoniae remains a major contributor to morbidity and mortality worldwide, particularly in neonatal intensive care units (NICUs). The emergence of car...

Research Square 2026-04-21 rs-9397022
Neonatal sepsis Klebsiella pneumoniae carbapenem resistance meropenem antimicrobial susceptibility testing in vitro–in vivo discordance

Dun Liu, Aierken Rehemutula, Zihao Chen, Yu Si, Hongyu Zhou, LI LI

Purpose To systematically evaluate the clinical efficacy and safety of antibiotic-loaded calcium sulfate (ALCS) as a local antibiotic delivery system for the treatment of osteomyelitis in adult patien...

Research Square 2026-04-21 rs-9416548
Osteomyelitis Antibiotic-loaded calcium sulfate Local antibiotic delivery Meta-analysis Systematic review Infection eradication Bone healing Biodegradable carrier

Fabio Grassia, Muhammad Riaz

Background Trigeminal neuralgia (TN) is one of the most severe pain syndromes in clinical medicine, with a prevalence of 4–13 per 100,000 annually. A substantial proportion of patients require surgica...

Research Square 2026-04-21 rs-9456237
trigeminal neuralgia scoping review microvascular decompression stereotactic radiosurgery percutaneous rhizotomy neurovascular conflict PRISMA-ScR clinical algorithm ICHD-3 peripheral nerve stimulation

Saifeldin A. Hassan, Jaynell Hannah R. Atmosfera, Yasmeen Aboussaf

Tracheal neoplasms are rare, accounting for a very small proportion of respiratory tract malignancies. Tracheal chondrosarcoma is an exceptionally uncommon tumor, with fewer than 40 cases reported in ...

Research Square 2026-04-21 rs-9388471
Bronchoscopy Chondrosarcoma Extra-luminal Tracheal neoplasms

Solomon Tessega

Background: Cervical cytology–histology correlation (CHC) is a key component of quality assurance (QA) in gynecologic cytopathology, enabling assessment of diagnostic concordance and identification of...

Research Square 2026-04-21 rs-9460175

Sara Alferjani, Mohamed HADi Mohamed Abdelhamid, Amal Benkorah

Background: Antiretroviral stock-outs in conflict-affected regions like Libya disrupt essential HIV treatment, risking viral suppression and health outcomes. However, the specific clinical impact of t...

Research Square 2026-04-21 rs-9451632
HIV antiretroviral stock-outs viral load suppression adherence co-infection digital health Libya

Sophie Tonneau, Denis Ispan, Gyuntae Bae, Jannik Sprengel, Frederic Dalle, Nicolas Beziere, Christoph Trautwein

Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus) are major opportunistic species, classified by the World Health Organization(WHO) in 2022 as critical priority pathogen due to t...

Research Square 2026-04-21 rs-9059703
Candida albicans Aspergillus fumigatus fungal interaction metabolic exchange profiling H-1-NMR timsTOF LC-MS

Carmen Fernández-González, Hichem Saoudi, Celia Mazariegos-Iglesias, Beatriz de la Calle, Francisco Javier Díaz-Pernas, Míriam Antón-Rodríguez, David González-Ortega, Daniel Iordanov, Mario Martínez-Zarzuela

Precise characterization of gait patterns is essential for the clinical assessment of motor disorders, such as cerebral palsy (CP) and idiopathic toe walking (ITW). While laboratory-based motion captu...

Research Square 2026-04-21 rs-9471086

Margareth C. Ozelo, Bruna Webler, Julia Lima, Mariana Alves, Ana Karolina de Nunes, Ana Dantas, Rodrigo F. Alexandre, Daniela V. Pachito, Ieda Solange de Souza Pinto

Background: Despite therapeutic advances, important gaps persist in hemophilia care within public healthcare systems in middle-income countries. In Brazil, universal access to prophylaxis is ensured t...

Research Square 2026-04-21 rs-9471111
Hemophilia A Hemophilia B Needs Assessment Medication adherence Delphi Technique Brazil

Tan Haosheng, Yu Dapeng, Jiao lianghe

Background Tumor epithelial barriers physically impede immune cell infiltration, causing immune exclusion and resistance to immune checkpoint inhibitors (ICIs). However, a simple, spatially quantifiab...

Research Square 2026-04-21 rs-9472940
epithelial barrier signature spatial transcriptomics immune exclusion immunotherapy outcome
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