11 results found

Peng Zhan, Gengbin Liu, Hongxing Cui, Zhengguang Zhang, Zhao Jing, Shengpeng Wang

Mesoscale eddies are major regulators of air-sea heat exchange, yet their climatic impact has been assessed mainly through changes in eddy frequency or amplitude, implicitly assuming that the spatial ...

Nature Portfolio 2026-04-23 rs-9380272

Tao Qin, Wenlong Huang, Changwei Yang, Tianming Lu, Jun Wang, Jie Chen, Linke Lu, Linli Chen, Tianyu Yan, Tingting Qian, Hao Yang, Defa Huang, Minghong Zhao

Objective To delineate the distinct immunometabolic perturbations in HIV-associated acute exacerbation of chronic obstructive pulmonary disease (HIV-AECOPD) and to identify circulating biomarkers pred...

BMC Infectious Diseases 2026-04-23 rs-9109705
HIV AECOPD CRP Biomarker Immune Dysregulation Prognosis

Ce Shi, Lihua Wu, Qiqi Yang, Fei Wang, Xiang Shang, Tianxin Jiang, Baoguo Wang, Jianhong Gao, Weiran Li, Ziyu Ye, Fei Li

Background Stroke contributes to cognitive impairment, but vulnerability varies. Education, a proxy for cognitive reserve and social advantage, may modify stroke-related orientation problems; evidence...

Scientific Reports 2026-04-23 rs-8765346
stroke orientation impairment educational attainment cognitive reserve effect modification older adults CHARLS

Rentong Liu, Bing Li, Yiqian Luo, Xiuwei Yan, Yuanyuan Wang, Song Jiang, Chengjie Gan, Yiwei Cheng

Liver Hepatocellular carcinoma (LIHC) is a highly heterogeneous malignancy with poor prognosis, underscoring the urgent need for reliable biomarkers and therapeutic targets. Cellular senescence plays ...

Discover Oncology 2026-04-23 rs-9198475
Hepatocellular carcinoma Cellular senescence Prognostic signature Tumor microenvironment

Hiroyuki Sasakura, Moribe Hiroki, Kazuto Ikemoto, Masashi Ikeno, Yuki Morioka, Yuka Takeuchi, Kosei Takeuchi

Pyrroloquinoline quinone (PQQ) is a multifunctional natural coenzyme that plays important roles in innate immunity, nutritional physiology, and redox biology, including the activation of dual oxidases...

Scientific Reports 2026-04-22 rs-9310397
Pyrroloquinoline quinone (PQQ) chemical modification monomethyl ester dual oxidase (DUOX) reactive oxygen species Caenorhabditis elegans

Yu-Ling Huang, Zheng-Yang Niu, Jing-Bo Ni, Tien Chinh Vu, Jian-Quan Chen, Yi-Hua Tong, Nian-He Xia

Three-branched bamboo is a taxonomically difficult group due to recent rapid radiation and frequent hybridization, with generic and species delimitation of many taxa problematic. Indosasa solearis, de...

BMC Plant Biology 2026-04-21 rs-9308077
Bamboo Morphology Phylogenomic Population genetics Gene flow

Umair Arif

Adverse pregnancy outcomes (APOs), including preeclampsia, preterm birth, and maternal heart failure, pose substantial risks for women with pre-existing heart disease. Soluble ST2 (sST2), a biomarker ...

Research Square 2026-04-21 rs-9459444
Adverse Pregnancy Outcomes (APOs) Soluble ST2 (sST2) Dendritic Neural Model (DNM) CTGAN Data Augmentation Risk Stratification Interpretability

Christian Ballardo Medina, Jaime Matus Rojas, Paul Humberto Valdez Castillejo, Eduardo Esau Luna Madrid

Background Preoperative identification of patients at risk for severe operative difficulty during laparoscopic cholecystectomy remains clinically relevant. C-reactive protein (CRP) reflects systemic i...

BMC Surgery 2026-04-21 rs-9257177
Laparoscopic cholecystectomy Acute calculous cholecystitis C-reactive protein Postoperative complications Parkland grading scale

Tan Haosheng, Yu Dapeng, Jiao lianghe

Background Tumor epithelial barriers physically impede immune cell infiltration, causing immune exclusion and resistance to immune checkpoint inhibitors (ICIs). However, a simple, spatially quantifiab...

Research Square 2026-04-21 rs-9472940
epithelial barrier signature spatial transcriptomics immune exclusion immunotherapy outcome

Tianzhu Shen, Hongfei Shen, Yun Kong, Weidong Qiang, Xinwei Yu, Jiaping Wang

Apurinic/apyrimidinic endonuclease 1 (APE1) is a key enzyme in the base excision repair (BER) pathway, and its aberrant overexpression is closely associated with poor prognosis, enhanced invasiveness,...

Scientific Reports 2026-04-20 rs-9308995
APE1 virtual screening molecular docking molecular dynamics simulation MM/GBSA anticancer drug discovery
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