103 results found

Pitithat Puranachot, Thivaratana Sinthuwiwat, Priyavudh Herabutya, Kanthida Jangyubol, Bongkod Petcharat, Jutamas Yimnoon, Jitsopin Phadungsut, Chayanee Samdaengpan, Chumut Phanthunane

Background: Accurately predicting treatment outcomes in patients with advanced non-small cell lung cancer (NSCLC) remains a significant clinical challenge. While circulating tumor DNA (ctDNA) within p...

BMC Personalized Medicine 2026-04-21 rs-9258115
Liquid biopsy monitoring Cell-free DNA Non-small cell lung cancer Progression-free survival Copy-number alterations cfDNA fragmentation Low-coverage whole-genome sequencing

Minxin He, Haibin Zhou, Xiangyu Wang, Mingrui Li, Tie Chong

Purpose: Early diagnosis of tumor recurrence or metastasis is critical for prolonging survival in patients with tumor. Such diagnosis requires not only high accuracy and flexibility but also clinical ...

Research Square 2026-04-21 rs-9434036
renal cell carcinoma circulating tumor cells blood cell counts prognosis inflammation-related indicator

Fabio Grassia, Muhammad Riaz

Background Trigeminal neuralgia (TN) is one of the most severe pain syndromes in clinical medicine, with a prevalence of 4–13 per 100,000 annually. A substantial proportion of patients require surgica...

Research Square 2026-04-21 rs-9456237
trigeminal neuralgia scoping review microvascular decompression stereotactic radiosurgery percutaneous rhizotomy neurovascular conflict PRISMA-ScR clinical algorithm ICHD-3 peripheral nerve stimulation

Tan Haosheng, Yu Dapeng, Jiao lianghe

Background Tumor epithelial barriers physically impede immune cell infiltration, causing immune exclusion and resistance to immune checkpoint inhibitors (ICIs). However, a simple, spatially quantifiab...

Research Square 2026-04-21 rs-9472940
epithelial barrier signature spatial transcriptomics immune exclusion immunotherapy outcome

Jeremy Slater, Gardar Thorvardsson

The transition from effortful to automatic processing is a defining feature of skill acquisition, and converging evidence implicates theta-gamma phase-amplitude coupling as the neural signature of thi...

Research Square 2026-04-21 rs-9465047
Equilibrium Propagation Landau-Ginzburg wave field holographic readout hierarchical predictive coding backpropagation-free learning theta-gamma phase-amplitude coupling Chrono-Resonant Field Model hierarchical automaticity predictive processing Kuramoto order parameter continuous wave field computing underdamped settling dynamics photonic neural networks neuromorphic computing TIMIT speech recognition

Jun Yu, Jie Huang, Qinghua Ma, Yanyu Chen, Xinyue Huang, Jian Chen

Background: Sarcopenia represents a highly prevalent and prognostically detrimental complication in patients with bone tumors. Its progressive and dynamic nature hinders early intervention and amplifi...

BMC Musculoskeletal Disorders 2026-04-21 rs-9305260
Bone Neoplasms Sarcopenia Risk Assessment Predictive Model Nomogram Prognosis

Maurice Wanyonyi, Dominic Kitavi, Faith Mueni, Zakayo Ndiku

Stroke remains a major global health burden and is a frequent and severe complication among patients with coronary heart disease (CHD). Early identification of individuals at high risk is essential fo...

Scientific Reports 2026-04-21 rs-8864270
Stroke risk prediction Coronary heart disease Machine learning Explainable artificial intelligence

Yan Jun Lin

Background: Mutations in intermediate filament genes cause over 100 human diseases, yet predicting clinical severity from genotype remains unreliable due to phenotypic variability and the prevalence o...

Human Genetics 2026-04-21 rs-9257849
intermediate filament FoldX ΔΔG variant interpretation genotype–phenotype correlation protein stability

Yongting Yuan, Jun Liu, Feng Wei, Chen Lin, Huihui Li, Yingpei Gu, Ruohua Gu, Yifeng Shen, Hanzhao Liu

Background:Mosquito-borne viruses are increasingly contributing to the global burden of human diseases. Among more than 500 recognized arboviruses, approximately 150 infect humans, and around 50 affec...

Parasites & Vectors 2026-04-21 rs-9289934
Virus Aedes albopictus Culex pipiens pallens Blood Meal Sources

Sanaz Ajabshir, Rishi Gupta

Concrete durability is strongly affected by microcracking, which facilitates the ingress of water and chloride ions and accelerates deterioration. Cellulose fibers represent a sustainable alternative ...

Discover Civil Engineering 2026-04-21 rs-9286512
Cellulose fibers NaOH treatment fiber-reinforced concrete Self-healing concrete Water permeability Chloride resistance
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