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Open Access Academic Papers from Research Square

2 results found
Research Article under-review

Integration of bulk and single-cell RNA-seq data identifies a cellular senescence-related prognostic signature in liver hepatocellular carcinoma

Rentong Liu, Bing Li, Yiqian Luo, Xiuwei Yan, Yuanyuan Wang, Song Jiang, Chengjie Gan, Yiwei Cheng

Liver Hepatocellular carcinoma (LIHC) is a highly heterogeneous malignancy with poor prognosis, underscoring the urgent need for reliable biomarkers and therapeutic targets. Cellular senescence plays ...

Discover Oncology 2026-04-23 rs-9198475
Hepatocellular carcinoma Cellular senescence Prognostic signature Tumor microenvironment
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Research Article under-review

Starvation-induced global chromatin compaction coexists with selective transcriptional activation

Xiyuan Qi, Sergei Muslinov, Konstantin I. Panov

Background Chromatin accessibility is widely used as a proxy for transcriptional potential, based on the premise that open chromatin promotes transcription factor binding and gene activation. Techniqu...

BMC Genomics 2026-04-21 rs-9252423
chromatin accessibility transcription stress response starvation RNA-seq ATAC-seq integrative genomics
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