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Open Access Academic Papers from Research Square

2 results found
Research Article under-review

Integration of bulk and single-cell RNA-seq data identifies a cellular senescence-related prognostic signature in liver hepatocellular carcinoma

Rentong Liu, Bing Li, Yiqian Luo, Xiuwei Yan, Yuanyuan Wang, Song Jiang, Chengjie Gan, Yiwei Cheng

Liver Hepatocellular carcinoma (LIHC) is a highly heterogeneous malignancy with poor prognosis, underscoring the urgent need for reliable biomarkers and therapeutic targets. Cellular senescence plays ...

Discover Oncology 2026-04-23 rs-9198475
Hepatocellular carcinoma Cellular senescence Prognostic signature Tumor microenvironment
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Research Article under-review

Single-Cell and Spatial Transcriptomics Identify Astrocyte Regulation of the Microenvironment and Prognosis in High-Grade Gliomas

Chang Ge, Wenjie Zhang, Pengcheng Zhang, Jingxuan Xu

Background: High-grade glioma is a highly malignant primary tumor of the central nervous system characterized by a poor clinical prognosis. The regulatory mechanisms of astrocytes within its TME are n...

European Journal of Medical Research 2026-04-21 rs-9156282
High-grade glioma Astrocytes Tumor microenvironment Prognostic marker Immune infiltration Cell-cell communication
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