Obesity-related metabolic disease is linked to impaired adipose tissue function, but the underlying molecular programs are difficult to assign to specific adipose-resident cell types, to mechanistical...
Glycosylation is a key structural modification of immunoglobulin G (IgG) that modulates its effector functions and has multiple roles in balancing inflammation. Altered IgG glycosylation has been repo...
Met1-linked ubiquitin (Met1-Ub) assembled by LUBAC crucially regulates immune receptor signalling. However, the regulation of LUBAC’s function remains widely debated. Here, we reveal that the interact...
Glycyrrhiza glabra(liquorice) is a widely used medicinal plant for treating inflammatory and respiratory disorders. Its major bioactive compound, glycyrrhetinic acid (GA), exerts anti-inflammatory and...
Purpose: Early diagnosis of tumor recurrence or metastasis is critical for prolonging survival in patients with tumor. Such diagnosis requires not only high accuracy and flexibility but also clinical ...
Vagus nerve stimulation modulates LPS-induced epileptogenicity: the role of inflammation suppression
Sustained systemic inflammation causes neuroinflammation and increases seizure risk, yet mechanisms linking inflammation and epileptogenicity remain poorly understood. Vagus nerve stimulation (VNS) su...
SinoXiv