29 results found

Rentong Liu, Bing Li, Yiqian Luo, Xiuwei Yan, Yuanyuan Wang, Song Jiang, Chengjie Gan, Yiwei Cheng

Liver Hepatocellular carcinoma (LIHC) is a highly heterogeneous malignancy with poor prognosis, underscoring the urgent need for reliable biomarkers and therapeutic targets. Cellular senescence plays ...

Discover Oncology 2026-04-23 rs-9198475
Hepatocellular carcinoma Cellular senescence Prognostic signature Tumor microenvironment

Delia Franchini, Stefano Ciccarelli, Cosimo Assumma, Ilaria Laino, Antonio Di Bello, Chiara D’Abramo, Chiara Perrone, Enrico Paolo Spugnini

Tumors are complex microenvironments in which uncontrolled cell proliferation alters biochemical pathways as well as the physical and electrical properties of tissues. Electrochemotherapy (ECT) exploi...

Scientific Reports 2026-04-23 rs-8592493
resistance tumor biphasic pulses bleomycin cat

Ahmed mahmoud mohamed galal

Background: Endobronchial hamartoma is a rare benign tumor of the tracheobronchial tree, accounting for approximately 10% of pulmonary hamartomas. Despite its benign nature, it may lead to significant...

The Egyptian Journal of Bronchology 2026-04-22 rs-8500013
Endobronchial hamartoma obstructive pneumonia bronchoscopy cryotherapy benign lung tumor

Xin Zhang, Houjun Jiang, Cheng Chen, Jianhua Ma

Objective To investigates the role of serum interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) levels as prognostic biomarkers in patients receiving First-Line Platinum-Based Chemotherapy Combine...

Journal of Cancer Research and Clinical Oncology 2026-04-22 rs-9242248
Non-small cell lung cancer Immunotherapy platinum-based chemotherapy Efficacy prediction Interleukin-6 Tumor necrosis factor-α

Lamin Makalo, M. Jaiteh, A. Manneh, R. Komma, M. Y Sesay, F. I Tambajang, O. Leigh, H. Ebel

Background: Inflammatory myofibroblastic tumor (IMT) is a rare, intermediate-grade neoplasm of the airway that can present with nonspecific respiratory symptoms, often mimicking asthma. In resource-li...

Research Square 2026-04-22 rs-9456021
inflammatory myofibroblastic tumor tracheal granuloma pediatric airway obstruction malnutrition recurrence bronchoscopy

Qi Wu, Zhijie Gao, Wei Pei, Ping Wang, Xin Yu, XinXin Rao, Ye Yao, Zhiyuan Liu, Ruiqing He, Enming Tian, Yanrong Yang, Bei Li, Tingting Niu, Yunqing Liu, Zhiyu Li, Hongmei Zheng, Heping Zhang, Oliver Kepp, Guido Kroemer, Lan Fang, Ping Wang

Subnuclear compartmentalization has emerged as a critical determinant of transcriptional homeostasis and cell-fate determination. The nucleolus scaffolds specialized heterochromatin, yet the mechanism...

Nature Portfolio 2026-04-22 rs-8897065
Deubiquitination Genome compartmentalization Heterochromatin Immunogenicity

Jiangyang Li, Xianfeng Lu, Shuai Yue, Ruyi Hang, Xiaoyan Dai, Xunjie Kuang, Wei Guo, Zhou Huang, Yanli Xiong, Mengxia Li

Non-small cell lung cancer (NSCLC) patients carrying HER2 20ins exon 20 insertion (HER2 20ins) are poorly respond to conventional therapies and pan HER inhibitors. Trastuzumab Deruxtecan (T-DXd) has b...

Scientific Reports 2026-04-22 rs-8854444
HER2 (ERBB2) NSCLC Deruxtecan (T-DXd DS-8201) Genomic instability Immune microenvironment

Jiaxuan Tian, Jinghui Dong, Guangqian Ren, Xiaomeng Li, Lihong Xing, Liyong Zhuo, Xueyan Liu, Shuo Dai, Yanyan Zhang, Hongjun Li, Xiaoping Yin, Linyan Xue

Objective To develop and validate a Union Model integrating clinical features with radiomics signatures derived from intratumoral and peritumoral T2-weighted imaging (T2WI) and diffusion-weighted imag...

BMC Cancer 2026-04-22 rs-9155751
Intrahepatic mass-forming cholangiocarcinoma p53 Magnetic resonance imaging Radiomics Peritumoral

Wenjie Yang, Chenxi Li, Yuheng Niu, Xin Jiang, Zhifang Ma

Background: Clear cell renal cell carcinoma (ccRCC) is the most prevalent and aggressive subtype of renal cell carcinoma, characterized by high recurrence rates and unfavorable prognosis. Identificati...

Scientific Reports 2026-04-21 rs-8769917
clear cell renal cell carcinoma ENPP4 prognostic biomarker tumor progression The Cancer Genome Atlas

Wang Zhe, Xiong Yan

Radiotherapy (RT) is integral to the management of head and neck squamous cell carcinoma (HNSCC), yet no validated biomarker exists to predict which patients benefit most. Lactylation, a metabolic pos...

Discover Oncology 2026-04-21 rs-9250884
Head and neck squamous cell carcinoma Lactylation Radiosensitivity Predictive biomarker Tumor immune microenvironment
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