Liver Hepatocellular carcinoma (LIHC) is a highly heterogeneous malignancy with poor prognosis, underscoring the urgent need for reliable biomarkers and therapeutic targets. Cellular senescence plays ...
Tumors are complex microenvironments in which uncontrolled cell proliferation alters biochemical pathways as well as the physical and electrical properties of tissues. Electrochemotherapy (ECT) exploi...
Background: Endobronchial hamartoma is a rare benign tumor of the tracheobronchial tree, accounting for approximately 10% of pulmonary hamartomas. Despite its benign nature, it may lead to significant...
Objective To investigates the role of serum interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) levels as prognostic biomarkers in patients receiving First-Line Platinum-Based Chemotherapy Combine...
Background: Inflammatory myofibroblastic tumor (IMT) is a rare, intermediate-grade neoplasm of the airway that can present with nonspecific respiratory symptoms, often mimicking asthma. In resource-li...
Subnuclear compartmentalization has emerged as a critical determinant of transcriptional homeostasis and cell-fate determination. The nucleolus scaffolds specialized heterochromatin, yet the mechanism...
Non-small cell lung cancer (NSCLC) patients carrying HER2 20ins exon 20 insertion (HER2 20ins) are poorly respond to conventional therapies and pan HER inhibitors. Trastuzumab Deruxtecan (T-DXd) has b...
Objective To develop and validate a Union Model integrating clinical features with radiomics signatures derived from intratumoral and peritumoral T2-weighted imaging (T2WI) and diffusion-weighted imag...
Background: Clear cell renal cell carcinoma (ccRCC) is the most prevalent and aggressive subtype of renal cell carcinoma, characterized by high recurrence rates and unfavorable prognosis. Identificati...
Radiotherapy (RT) is integral to the management of head and neck squamous cell carcinoma (HNSCC), yet no validated biomarker exists to predict which patients benefit most. Lactylation, a metabolic pos...
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